Rooting out scientific misconduct.

Scientific misconduct is an issue rife with controversy, from its forms and definitions to the policies that guide how allegations are handled. A survey published nearly 15 years ago reported that 2% of researchers said they had fabricated or falsified data in their published work. This is not just an academic issue. Fake data promote ineffective or even dangerous treatments, for example, and thwart the discovery of real solutions for society. In the United States, the Office of Research Integrity (ORI) is tasked with rooting out misconduct in research funded by the National Institutes of Health (NIH). Last October, ORI proposed changes to how it functions. The agency's recommendations-the first since 2005-have evoked mixed reactions, but the real problem is that ORI is underfunded and lacks the resources and authority needed to make a difference. Unless its charter is revised by Congress, the ORI can sadly do little more than tinker at the edges of scientific fraud.

Characteristics of Retracted Research Articles About COVID-19 vs Other Topics.

This cross-sectional study compares the author and journal characteristics of retracted articles on COVID-19 with retracted articles from other topics.

An "alarming" and "exceptionally high" rate of COVID-19 retractions?

More than 20 papers about COVID-19 have been retracted at the time of this writing. It is premature, however, to conclude that such work is being retracted at higher rates than the rest of the literature.

Will Improvements in Health Journalism Improve Health Literacy?

Today's health care journalists work in a very different environment than those of yesterday. The demand for stories and broadcasts has grown exponentially, and the resources available have shrunk dramatically. While it may therefore be difficult to see how improvements in health care journalism are possible, let alone a way to improve health care literacy, there is an important connection that, if illuminated, could help both fields. To understand the literature on the quality of health care journalism, it is critical to understand the backgrounds of today's health care journalists and the challenges they face. That literature also goes hand in hand with studies of the effects that news coverage has on the public's understanding of health care issues. There are training and educational programs designed to help health care journalists do their jobs better, and this chapter concludes with a discussion of how cooperation between health journalists, physicians, and other stakeholders can lift all boats.

Correction to: Three randomized controlled trials evaluating the impact of "spin" in health news stories reporting studies of pharmacologic treatments on patients'/caregivers' interpretation of treatment benefit.

Figure 3 in the original article [1] is incorrect; labels for secondary outcomes have been shifted and do not correspond to the numbers reported in the table (Additional file 8). The corrected version can be seen ahead. This figure should be used over the figure 3 seen in the original article. This error does not affect the results, interpretation, or conclusion.

Three randomized controlled trials evaluating the impact of "spin" in health news stories reporting studies of pharmacologic treatments on patients'/caregivers' interpretation of treatment benefit.

BACKGROUND: News stories represent an important source of information. We aimed to evaluate the impact of "spin" (i.e., misrepresentation of study results) in health news stories reporting studies of pharmacologic treatments on patients'/caregivers' interpretation of treatment benefit. METHODS: We conducted three two-arm, parallel-group, Internet-based randomized trials (RCTs) comparing the interpretation of news stories reported with or without spin. Each RCT considered news stories reporting a different type of study: (1) pre-clinical study, (2) phase I/II non-RCT, and (3) phase III/IV RCT. For each type of study, we identified news stories reported with spin that had earned mention in the press. Two versions of the news stories were used: the version with spin and a version rewritten without spin. Participants were patients/caregivers involved in Inspire, a large online community of more than one million patients/caregivers. The primary outcome was participants' interpretation assessed by one specific question "What do you think is the probability that 'treatment X' would be beneficial to patients?" (scale, 0 [very unlikely] to 10 [very likely]). RESULTS: For each RCT, 300 participants were randomly assigned to assess a news story with spin (n = 150) or without spin (n = 150), and 900 participants assessed a news story. Participants were more likely to consider that the treatment would be beneficial to patients when the news story was reported with spin. The mean (SD) score for the primary outcome for abstracts reported with and without spin for pre-clinical studies was 7.5 (2.2) versus 5.8 (2.8) (mean difference [95% CI] 1.7 [1.0-2.3], p < 0.001); for phase I/II non-randomized trials, 7.6 (2.2) versus 5.8 (2.7) (mean difference 1.8 [1.0-2.5], p < 0.001); and for phase III/IV RCTs, 7.2 (2.3) versus 4.9 (2.8) (mean difference 2.3 [1.4-3.2], p < 0.001). CONCLUSIONS: Spin in health news stories reporting studies of pharmacologic treatments affects patients'/caregivers' interpretation. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03094078 , NCT03094104 , NCT03095586.

Analysis of retracted articles in the surgical literature.

BACKGROUND: Retractions of scientific articles represent attempts to correct the literature. Our goal was to examine retracted surgical papers. METHODS: NCBI PubMed database was queried using the search terms "surgery," "surg," or "surgical" and "retracted" or "retraction." Article details were recorded. RESULTS: There were 184 retracted surgical articles identified from 1991 through 2015. Average retraction time was 3.6 years. General (26%), Cardiac (22%), and Orthopedic (10%) surgery were most common. Reasons for retraction were duplication (35.3%), Institutional Review Board violations (18.5%), falsified data (14.7%), data errors (9.8%), author dispute (8.2%), plagiarism (7.6%), copyright violations (2.2%), financial disclosure violations (0.5%), and consent (0.5%). No reason for retraction was given in 8.7% of cases. Median IF was higher for administrative than content-related retraction reasons (3.0 vs. 2.0, P < 0.01). A paywall, requiring a subscription to read, restricted access to 23.4% of retraction notices. CONCLUSIONS: Article retractions occur across all fields of surgery for various reasons, both administrative and content-related. The majority of surgical retraction notices have a reason for retraction listed and do not require payment to read.

Interpretation of health news items reported with or without spin: protocol for a prospective meta-analysis of 16 randomised controlled trials.

INTRODUCTION: We aim to compare the interpretation of health news items reported with or without spin. 'Spin' is defined as a misrepresentation of study results, regardless of motive (intentionally or unintentionally) that overemphasises the beneficial effects of the intervention and overstates safety compared with that shown by the results. METHODS AND ANALYSIS: We have planned a series of 16 randomised controlled trials (RCTs) to perform a prospective meta-analysis. We will select a sample of health news items reporting the results of four types of study designs, evaluating the effect of pharmacological treatment and containing the highest amount of spin in the headline and text. News items reporting four types of studies will be included: (1) preclinical studies; (2) phase I/II (non-randomised) trials; (3) RCTs and (4) observational studies. We will rewrite the selected news items and remove the spin. The original news and rewritten news will be appraised by four types of populations: (1) French-speaking patients; (2) French-speaking general public; (3) English-speaking patients and (4) English-speaking general public. Each RCT will explore the interpretation of news items reporting one of the four study designs by each type of population and will include a sample size of 300 participants. The primary outcome will be participants' interpretation of the benefit of treatment after reading the news items: (What do you think is the probability that treatment X would be beneficial to patients? (scale, 0 (very unlikely) to 10 (very likely)).This study will evaluate the impact of spin on the interpretation of health news reporting results of studies by patients and the general public. ETHICS AND DISSEMINATION: This study has obtained ethics approval from the Institutional Review Board of the Institut national de la santé et de la recherche médicale (INSERM) (registration no: IRB00003888). The description of all the steps and the results of this prospective meta-analysis will be available online and will be disseminated as a published article. On the completion of this study, the results will be sent to all participants. PROSPERO REGISTRATION NUMBER: CRD42017058941.

What studies of retractions tell us.

The retraction is receiving a growing amount of attention as an important event in scientific and scholarly publishing. Not only are some journals becoming increasingly open in their handling of the articles they withdraw-allowing researchers to gain important insights into the work of their colleagues-but scholars, too, have greater access to the reasons for retractions, information that is dramatically reshaping our understanding of such events. As this article will demonstrate, recent research has inverted the accepted lore about why retractions happen and their impact.